High-Resolution Sequence-Function Mapping of Full-Length Proteins
نویسندگان
چکیده
منابع مشابه
High-Resolution Sequence-Function Mapping of Full-Length Proteins
Comprehensive sequence-function mapping involves detailing the fitness contribution of every possible single mutation to a gene by comparing the abundance of each library variant before and after selection for the phenotype of interest. Deep sequencing of library DNA allows frequency reconstruction for tens of thousands of variants in a single experiment, yet short read lengths of current seque...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0118193